Beth, Calvin, and their son Conrad are living in the aftermath of the death of the other son. Conrad is overcome by grief and misplaced guilt to the extent of a suicide attempt. He is in therapy. Beth had always preferred his brother and is having difficulty being supportive to Conrad. Calvin is trapped between the two trying to hold the family together.

The deranged adventures of Gonzo journalist Hunter Thompson and his attorney Oscar Acosta, referred to in the movie as "Laslow". Thompson attempts to cover the Super Bowl and the 1972 Presidential election in his typical drug-crazed state, but it continually and comically sidetracked by his even more twisted friend Laslow. Allegedly based on actual events.